Arg-gingipains (RgpA and RgpB) and Lys-gingipain (Kgp) are responsible for the majority of bacterial proteolytic activity and play essential roles in bacterial virulence. Therefore, gingipains are often considered as therapeutic targets.

The GAIN (GingipAIN Inhibitor for Treatment of Alzheimer’s Disease) Trial is based on a growing body of scientific evidence that the bacteria P. gingivalis, most commonly associated with degenerative gum disease, can infect the brain and cause Alzheimer’s disease.

From Wikipedia, the free encyclopedia Gingipain R (EC 3.4.22.37, Arg-gingipain, gingipain-1, argingipain, Arg-gingivain-55 proteinase, Arg-gingivain-70 proteinase, Arg-gingivain-75 proteinase, arginine-specific cysteine protease, arginine-specific gingipain, arginine-specific gingivain, RGP-1, RGP) is an enzyme. The GAIN (GingipAIN Inhibitor for Treatment of Alzheimer’s Disease) Trial is based on a growing body of scientific evidence that the bacteria P. gingivalis, most commonly associated with degenerative gum disease, can infect the brain and cause Alzheimer’s disease. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria.2 Publications Gingipains are the major virulence factors of Porphyromonas gingivalis, the main periodontopathogen.

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Materials and  The Arg-gingipains, RgpA and RgpB and Lys-gingipain Kgp are secreted from P. gingivalis as inactive prodomain-bearing precursors. The amino-terminal  In summary, gingipains are vital for bacterial survival and proliferation in vivo [7]. In the process of adherence and colonization, P. gingivalis utilizes fimbrial  Gingipains are trypsin-like cysteine proteinases produced by Porphyromonas gingivalis, a major causative bacterium of adult periodontitis. HRgpA (95 kDa) and  (3) Studies on the roles of Porphyromonas gingivalis-derived proteases on bone metabolism. We found that a lysine-specific gingipain degraded osteoprotegerin   5 May 2009 The most potent virulence factors of this bacterium are the gingipains, three cysteine proteases that bind and cleave a wide range of host proteins.

Posts about GingipAIN written by Simon.

Cortexyme report their COR388 gingipain blockers have entered the brain, have passed initial safety tests in humans, and seemed to improve those with AD. Larger trials will launched looking for Porphyromonas Gingivalis in spinal fluid and cognitive improvements, both before and after.

Its encoding region corresponds to 228-720aa of rgpA of Porphyromonas gingivalis-origin. This recombinant rgpA protein was validated … 2016-12-01 COR388 (atuzaginstat), a novel gingipain inhibitor, decreases ApoEfragmentation in the CNS of Alzheimer’s disease patients Debasish Raha1, Sean Broce1,Ursula Haditsch1,Leo Rodriguez1, Florian Ermini1, Michael Detke1, Shirin Arastu-Kapur1, Dave Hennings1, Mai Nguyen1, Leslie J. Holsinger1, Casey Lynch1, Stephen Dominy1 BACKGROUND It is, therefore, suggested that gingipain inhibition by vaccination and gingipain‐specific inhibitors is a useful therapy for adult periodontitis caused by P. gingivalis infection. J Periodontol 2003;74:111‐118.

Apart from its potent antimicrobial as well as antibiofilm properties, it also significantly inhibited the gingipains in a dose-dependent manner. At the minimal concentration of 17.826 μM, inhibition up to 98.7% and 89.4% was noted for gingipain R and K respectively.

393, 971–977 (2012).

Arg-gingipain is involved in this post-translational processing. 1 Publication 2008-07-01 Gingipains secreted by Porphyromonas gingivalis (P.
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Involved in the coaggregation of P.gingivalis with other oral bacteria.2 Publications Gingipains are the major virulence factors of Porphyromonas gingivalis, the main periodontopathogen. It is expected that inhibition of gingipain activity in vivo could prevent or slow down the Abstract Periodontitis is a biofilm-associated irreversible inflammation of the periodontal tissues. Reports suggest the role of Porphyromonas gingivalis specific Arg- and Lys-specific proteinases in the orchestration of the initiation and progression of periodontal diseases. Specifically, the gingipain inhibitor reduced deposits of lipids in the aortas of infected animals and prevented the progression of atherosclerosis linked to P. gingivalis infection.

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We identified the bacterial pathogen, Porphyromonas gingivalis (Pg), and its protease virulence factors, gingipains, in the brain of patients with Alzheimer’s disease (AD). Gingipain levels in AD brains were shown to significantly correlate with AD diagnosis and tau and ubiquitin pathology. The neurodegeneration and AD‐like pathology in Pg infected

Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-alpha and interleukin-1beta but suppresses that by Keywords:Alzheimer`s disease, cathepsin B, gingipain, microglia, neuroinflammation, periodontitis, Porphylomonas gingivalis. Abstract:Many efforts have been made to develop therapeutic agents for Alzheimer’s Disease (AD) based on the amyloid cascade hypothesis, but there is no effective therapeutic agent at present. 2019-03-20 · Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes. Biol. Chem. 393, 971–977 (2012).